| Pair Name | Tectorigenin, Paclitaxel | ||
| Phytochemical Name | Tectorigenin (PubChem CID: 5281811 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Tectorigenin, Paclitaxel | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Gene Regulation | Down-regulation | Activity | AKT1 | hsa207 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| Down-regulation | Phosphorylation | CHUK | hsa1147 | |
| Down-regulation | Phosphorylation | CHUK | hsa1147 | |
| Down-regulation | Expression | COX2 | hsa4513 | |
| Down-regulation | Phosphorylation | IKBKE | hsa9641 | |
| Down-regulation | Activity | NFKB1 | hsa4790 | |
| Down-regulation | Phosphorylation | NFKBIA | hsa4792 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | MPSC1 | Low grade ovarian serous adenocarcinoma | Homo sapiens (Human) | CVCL_9822 |
| A2780 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0134 | |
| SK-OV-3 | Ovarian serous cystadenocarcinoma | Homo sapiens (Human) | CVCL_0532 | |
| Result | These data suggest that tectorigenin could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFκB pathway. Carcinogenesis. 2012 Dec;33(12):2488-98. doi: 10.1093/carcin/bgs302. | Click |
